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Comparison of the effects of selective and nonselective muscarinic agonists on cognition and thermoregulation in primates.

Abstract:

Peripheral toxicity may explain the disappointing therapeutic effects of nonselective muscarinic agonists in Alzheimer's disease. Partial agonists might exhibit an improved therapeutic index. We compare the central and peripheral cholinergic effects of RS86 with the M1/M3 partial agonists AF 102B and L-689,660 ((-)-3-[2-6 chloropyrazin)yl]-1-azabicyclo[2.2.2]octane) in primates. Administration of RS86 (1.5-2.25 mg/kg i.m.) or L-689,660 (0.1-0.3 mg/kg i.m.), but not AF 102B (up to 6 mg/kg i.m....

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Journal of the neurological sciences
Volume:
110
Issue:
1-2
Pages:
222-227
Publication date:
1992-07-01
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
Source identifiers:
25025

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