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Journal article

Quantification of the anti-influenza drug zanamivir in plasma using high-throughput HILIC-MS/MS.

Abstract:

BACKGROUND: parenteral zanamivir is a promising drug for the treatment of severe influenza. However, quantification of this polar drug in biological matrices has traditionally been difficult and the methods developed have been relatively insensitive. RESULTS: a high-throughput bioanalytical method for the analysis of zanamivir in human plasma using SPE in the 96-well plate format and LC coupled to positive MS/MS has been developed and validated according to US FDA guidelines. The method uses ...

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Publication status:
Published

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Publisher copy:
10.4155/bio.10.189

Authors


Lindegardh, N More by this author
Hanpithakpong, W More by this author
Kamanikom, B More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Bioanalysis
Volume:
3
Issue:
2
Pages:
157-165
Publication date:
2011-01-05
DOI:
EISSN:
1757-6199
ISSN:
1757-6180
URN:
uuid:03de65c9-3d28-4624-ac35-87e2ae04a24a
Source identifiers:
115688
Local pid:
pubs:115688

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