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Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients

Abstract:
Background: MRS studies of acutely depressed patients reveal decreased levels of total glutamate and glutamine (Glx) in frontal cortex which may reflect abnormalities of glutamate-glutamine cycling through astrocytes. Frontal Glx levels appear to be normalised after recovery from depression, but it is not known if this composite measure masks ongoing differences in glutamate or glutamine alone. Methods: Medication-free, fully recovered patients with a history of DSM-IV recur... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Author's Original

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Publisher copy:
10.1016/j.jad.2009.02.022

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Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
More from this funder
Funding agency for:
Matthew J. Taylor
Publisher:
Elsevier Publisher's website
Journal:
Journal of Affective Disorders Journal website
Volume:
119
Issue:
1-3
Pages:
186-189
Publication date:
2009-12-06
DOI:
ISSN:
0165-0327
URN:
uuid:03c97d0e-075b-484c-8c31-70c26f5a68c3
Local pid:
ora:3668

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