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Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients

Abstract:
Background: MRS studies of acutely depressed patients reveal decreased levels of total glutamate and glutamine (Glx) in frontal cortex which may reflect abnormalities of glutamate-glutamine cycling through astrocytes. Frontal Glx levels appear to be normalised after recovery from depression, but it is not known if this composite measure masks ongoing differences in glutamate or glutamine alone. Methods: Medication-free, fully recovered patients with a history of DSM-IV recur... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jad.2009.02.022

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author

Contributors

Publisher:
Elsevier
Journal:
Journal of Affective Disorders More from this journal
Volume:
119
Issue:
1-3
Pages:
186-189
Publication date:
2009-12-01
DOI:
ISSN:
0165-0327
Language:
English
Keywords:
Subjects:
UUID:
uuid:03c97d0e-075b-484c-8c31-70c26f5a68c3
Local pid:
ora:3668
Deposit date:
2010-04-26

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