Journal article
A randomized comparison of chloroquine versus dihydroartemisinin-piperaquine for the treatment of Plasmodium vivax infection in Vietnam
- Abstract:
- A total of 128 Vietnamese patients with symptomatic Plasmodium vivax mono-infections were enrolled in a prospective, open-label, randomized trial to receive either chloroquine or dihydroartemisinin-piperaquine (DHA-PPQ). The proportions of patients with adequate clinical and parasitological responses were 47% in the chloroquine arm (31 of 65 patients) and 66% in the DHA-PPQ arm (42 of 63 patients) in the Kaplan-Meier intention-to-treat analysis (absolute difference 19%, 95% confidence interval = 0-37%), thus establishing non-inferiority of DHA-PPQ. Fever clearance time (median 24 versus 12 hours, P = 0.02), parasite clearance time (median 36 versus 18 hours, P < 0.001), and parasite clearance half-life (mean 3.98 versus 1.80 hours, P < 0.001) were all significantly shorter in the DHA-PPQ arm. All cases of recurrent parasitemia in the chloroquine arm occurred from day 33 onward, with corresponding whole blood chloroquine concentration lower than 100 ng/mL in all patients. Chloroquine thus remains efficacious for the treatment of P. vivax malaria in southern Vietnam, but DHA-PPQ provides more rapid symptomatic and parasitological recovery.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 628.9KB, Terms of use)
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- Publisher copy:
- 10.4269/ajtmh.15-0740
Authors
- Publisher:
- American Society of Tropical Medicine and Hygiene
- Journal:
- American Journal of Tropical Medicine and Hygiene More from this journal
- Volume:
- 94
- Issue:
- 4
- Pages:
- 879-885
- Publication date:
- 2016-04-06
- Acceptance date:
- 2015-12-14
- DOI:
- EISSN:
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1476-1645
- ISSN:
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0002-9637
- Language:
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English
- Pubs id:
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pubs:601385
- UUID:
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uuid:03c239f4-eff4-40bb-aeb8-71805a049b2f
- Local pid:
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pubs:601385
- Source identifiers:
-
601385
- Deposit date:
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2016-03-15
- ARK identifier:
Terms of use
- Copyright holder:
- American Society of Tropical Medicine and Hygiene
- Copyright date:
- 2016
- Rights statement:
- Copyright © The American Society of Tropical Medicine and Hygiene. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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