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Journal article

Clinical assessment determines the diagnosis of inclusion body myositis independently of pathological features

Abstract:

Background and objective: Historically, the diagnosis of sporadic inclusion body myositis (IBM) has required the demonstration of the presence of a number of histopathological findings on muscle biopsy-namely, rimmed vacuoles, an inflammatory infiltrate with invasion of non-necrotic muscle fibres (partial invasion) and amyloid or 15-18 nm tubulofilamentous inclusions (Griggs criteria). However, biopsies of many patients with clinically typical IBM do not show all of these histopathological fi...

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Publisher copy:
10.1136/jnnp-2013-305690

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Journal of Neurology, Neurosurgery and Psychiatry
Volume:
84
Issue:
11
Pages:
1240-1246
Publication date:
2013-11-01
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Source identifiers:
436285
Language:
English
Pubs id:
pubs:436285
UUID:
uuid:03c041ea-cc51-4d59-9be1-df21fa5109a2
Local pid:
pubs:436285
Deposit date:
2013-11-16

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