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Journal article

Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor.

Abstract:

Cytoplasmic sorting of mRNAs by microtubule-based transport is widespread, yet very little is known at the molecular level about how specific transcripts are linked to motor complexes. In Drosophila, minus-end-directed transport of developmentally important transcripts by the dynein motor is mediated by seemingly divergent mRNA elements. Here we provide evidence that direct recognition of these mRNA localization signals is mediated by the Egalitarian (Egl) protein. Egl and the dynein cofactor...

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Publication status:
Published

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Publisher copy:
10.1101/gad.531009

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Genes and development
Volume:
23
Issue:
13
Pages:
1546-1558
Publication date:
2009-07-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Source identifiers:
55380
Language:
English
Keywords:
Pubs id:
pubs:55380
UUID:
uuid:03b25e26-c64f-4719-97f6-85582cddf911
Local pid:
pubs:55380
Deposit date:
2012-12-19

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