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Journal article

Bacterial membrane vesicles transport their DNA cargo into host cells

Abstract:

Bacterial outer membrane vesicles (OMVs) are extracellular sacs containing biologically active products, such as proteins, cell wall components and toxins. OMVs are reported to contain DNA, however, little is known about the nature of this DNA, nor whether it can be transported into host cells. Our work demonstrates that chromosomal DNA is packaged into OMVs shed by bacteria during exponential phase. Most of this DNA was present on the external surfaces of OMVs, with smaller amounts located i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-07288-4

Authors


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Role:
Author
ORCID:
0000-0003-1202-6614
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-5334-557X
Victorian Government More from this funder
Australian Government, Department of Industry, Innovation and Science More from this funder
Australian Research Council More from this funder
National Health and Medical Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
7072
Publication date:
2017-08-01
Acceptance date:
2017-06-27
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
28765539
Language:
English
Keywords:
Pubs id:
pubs:896306
UUID:
uuid:03b0defe-9469-4b5c-ae36-07016c8e1a3f
Local pid:
pubs:896306
Source identifiers:
896306
Deposit date:
2018-11-07

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