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Journal article

CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.

Abstract:

OBJECTIVE: The CD200 receptor (CD200R) is an inhibitory receptor expressed by myeloid cells that is postulated to play an important role in regulation of the immune system. The purpose of this study was to evaluate the efficacy of a soluble ligand of CD200R in established collagen-induced arthritis (CIA) in mice and to analyze changes in cytokine expression following therapy in order to understand its primary mechanism of action. METHODS: Arthritis was induced in DBA/1 mice, and CD200-Fc fus...

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Publication status:
Published

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Publisher copy:
10.1002/art.23378

Authors


Simelyte, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Arthritis and rheumatism
Volume:
58
Issue:
4
Pages:
1038-1043
Publication date:
2008-04-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:03b0c439-af22-45c4-8281-f50f852633dc
Source identifiers:
224650
Local pid:
pubs:224650

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