A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. I. Mortality and cardiovascular morbidity.

Journal article

UNLABELLED: The impact of perfusion technique and mode of pH management during cardiopulmonary bypass has not been well characterized with respect to postoperative cardiovascular outcome. METHODS: This double-blind, randomized study comparing outcomes after alpha-stat or pH-stat management and pulsatile or nonpulsatile perfusion during moderate hypothermic cardiopulmonary bypass was undertaken in 316 patients undergoing coronary artery bypass operations. RESULTS: Cardiovascular morbidity and mortality were not affected by pH management, and the incidence of stroke (2.5%) did not differ between groups. Overall in-hospital mortality was 2.8%, eight of the nine deaths occurring in the nonpulsatile group (5.1% versus 0.6%; p = 0.018). The incidence of myocardial infarction was 5.7% in the nonpulsatile group and 0.6% in the pulsatile group (p = 0.010), and use of intraaortic balloon pulsation was significantly more common in the nonpulsatile group (7.0% versus 1.9%; p = 0.029). The overall percentage of patients having major complications was also significantly higher in the nonpulsatile group (15.2% versus 5.7%; p = 0.006). Duration of cardiopulmonary bypass, age, and use of nonpulsatile perfusion all correlated significantly with adverse outcome. CONCLUSIONS: Use of pulsatile perfusion during cardiopulmonary bypass was associated with decreased incidences of myocardial infarction, death, and major complications.

Authors: Murkin, J; Martzke, J; Buchan, A; Bentley, C; Wong, C

• Publication status: Published
• Journal: Journal of thoracic and cardiovascular surgery
• Volume: 110
• Issue: 2
• Pages: 340-348
• Publication date: 1995-08-01
• DOI: 10.1016/s0022-5223(95)70229-6
• EISSN: 1097-685X
• ISSN: 0022-5223
• Language: English
• Keywords: Cerebrovascular Disorders; Carbon Dioxide; Hydrogen-Ion Concentration; Myocardial Infarction; Arrhythmias, Cardiac; Male; Humans; Female; Cardiopulmonary Bypass; Postoperative Care; Renal Insufficiency; Double-Blind Method; Aged; Middle Aged; Risk Factors; Pulsatile Flow; Blood Pressure; Coronary Artery Bypass; Prospective Studies; Postoperative Complications; Intra-Aortic Balloon Pumping