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Why are so many MLL lysine methyltransferases required for normal mammalian development?

Abstract:
The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and development. Here, we provide a brief history of the discovery and study of this family of proteins. We address two main questions: why are there so many H3K4 methyltransferases in mammals; and is H3K4 methylation their key function?
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1007/s00018-019-03143-z

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Oxford college:
St Peters College
Role:
Author
ORCID:
0000-0002-0413-4271
Publisher:
Springer Publisher's website
Journal:
Cellular and Molecular Life Sciences Journal website
Volume:
76
Issue:
15
Pages:
2885-2898
Publication date:
2019-05-16
Acceptance date:
2019-05-10
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
Pubs id:
pubs:1000086
URN:
uri:03ad425b-23b7-4a92-9d90-f1682b4ee9bf
UUID:
uuid:03ad425b-23b7-4a92-9d90-f1682b4ee9bf
Local pid:
pubs:1000086

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