- Abstract:
- The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and development. Here, we provide a brief history of the discovery and study of this family of proteins. We address two main questions: why are there so many H3K4 methyltransferases in mammals; and is H3K4 methylation their key function?
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.0MB)
-
- Publisher copy:
- 10.1007/s00018-019-03143-z
-
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- Publisher:
- Springer Publisher's website
- Journal:
- Cellular and Molecular Life Sciences Journal website
- Volume:
- 76
- Issue:
- 15
- Pages:
- 2885-2898
- Publication date:
- 2019-05-16
- Acceptance date:
- 2019-05-10
- DOI:
- EISSN:
-
1420-9071
- ISSN:
-
1420-682X
- Pubs id:
-
pubs:1000086
- URN:
-
uri:03ad425b-23b7-4a92-9d90-f1682b4ee9bf
- UUID:
-
uuid:03ad425b-23b7-4a92-9d90-f1682b4ee9bf
- Local pid:
- pubs:1000086
- Language:
- English
- Keywords:
- Copyright holder:
- Crump and Milne
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Journal article
Why are so many MLL lysine methyltransferases required for normal mammalian development?
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