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Harnessing invariant NKT cells in vaccination strategies.

Abstract:

To optimize vaccination strategies, it is important to use protocols that can 'jump-start' immune responses by harnessing cells of the innate immune system to assist the expansion of antigen-specific B and T cells. In this Review, we discuss the evidence indicating that invariant natural killer T (iNKT) cells can positively modulate dendritic cells and B cells, and that their pharmacological activation in the presence of antigenic proteins can enhance antigen-specific B- and T-cell responses....

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Publication status:
Published

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Publisher copy:
10.1038/nri2451

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
Journal:
Nature reviews. Immunology
Volume:
9
Issue:
1
Pages:
28-38
Publication date:
2009-01-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:03a64a51-1068-48c3-84d0-fb7985f2ca22
Source identifiers:
21202
Local pid:
pubs:21202

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