DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma.

Journal article

PURPOSE: DNA replication licensing factors and Aurora kinases play critical roles in maintaining genomic integrity. We used multiparameter analyses of these cell cycle regulatory proteins to investigate their role in the progression of epithelial ovarian carcinoma (EOC). EXPERIMENTAL DESIGN: In a cohort of 143 patients, we linked the protein expression profiles of the proliferation marker Ki67, the replication licensing factors Mcm2 and geminin, and the Aurora A and B kinases to tumor DNA pl...

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Authors: Kulkarni, A; Loddo, M; Leo, E; Rashid, M; Eward, K

• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
• Volume: 13
• Issue: 20
• Pages: 6153-6161
• Publication date: 2007-10-01
• DOI: 10.1158/1078-0432.ccr-07-0671
• EISSN: 1557-3265
• ISSN: 1078-0432
• Language: English
• Keywords: Hela Cells; Disease-Free Survival; Cell Cycle Proteins; Cohort Studies; Protein-Serine-Threonine Kinases; Ki-67 Antigen; Nuclear Proteins; Cell Cycle; Humans; Aneuploidy; Aged, 80 and over; Adult; Female; DNA; Middle Aged; DNA Replication; Neoplasms, Glandular and Epithelial; Aged; Ovarian Neoplasms