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Journal article

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.

Abstract:

Chemokines (CK) provide directional cues that mediate the recruitment of leukocytes to sites of inflammation. Broad-spectrum blockade of the CC-CK family, using the vaccinia virus 35K protein, has been shown to cause a potent reduction of systemic inflammation in models of atherosclerosis, vein graft disease and arthritis. We have used a cell membrane-targeted form of 35K, Mem35K, to probe whether cell-associated blockade of chemokine response is sufficient to reduce cell recruitment in infla...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00109-014-1194-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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British Heart Foundation More from this funder
Wellcome Trust More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Journal of molecular medicine (Berlin, Germany) Journal website
Volume:
92
Issue:
11
Pages:
1169-1178
Publication date:
2014-11-01
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
Source identifiers:
478427
Language:
English
Keywords:
Pubs id:
pubs:478427
UUID:
uuid:03a0211b-33f1-4404-b863-510c85fadcc7
Local pid:
pubs:478427
Deposit date:
2014-08-15

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