MicroRNA expression in Sezary syndrome: identification, function, and diagnostic potential.

Journal article

MicroRNAs are commonly aberrantly expressed in many cancers. Very little is known of their role in T-cell lymphoma, however. We therefore elucidated the complete miRNome of purified T cells from 21 patients diagnosed with Sézary Syndrome (SzS), a rare aggressive primary cutaneous T-cell (CD4(+)) lymphoma. Unsupervised cluster analysis of microarray data revealed that the microRNA expression profile was distinct from CD4(+) T-cell controls and B-cell lymphomas. The majority (104 of 114) of SzS...

Expand abstract

Authors: Ballabio, E; Mitchell, T; van Kester, MS; Taylor, S; Dunlop, H

• Publication status: Published
• Journal: Blood
• Volume: 116
• Issue: 7
• Pages: 1105-1113
• Publication date: 2010-08-01
• DOI: 10.1182/blood-2009-12-256719
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Mycosis Fungoides; Gene Expression Profiling; MicroRNAs; Oligonucleotide Array Sequence Analysis; Cell Proliferation; Apoptosis; Prognosis; Sezary Syndrome; Lymphoma, B-Cell; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Humans; Tumor Markers, Biological; Blotting, Western; Gene Expression Regulation, Neoplastic; Luciferases