Studies on circulating met-enkephalin and beta-endorphin: normal subjects and patients with renal and adrenal disease.

Smith, R; Grossman, A; Gaillard, R; Clement-Jones, V; Ratter, S; Mallinson, J; Lowry, P; Besser, G; Rees, L

Journal article

Studies on circulating met-enkephalin and beta-endorphin: normal subjects and patients with renal and adrenal disease.

Abstract:: Studies were performed to define the responses of plasma met-enkephalin to various endocrine and pathological stimuli and to determine the relationship 0,14656 between plasma β-endorphin and met-enkephalin. During insulin-induced hypoglycaemia ACTH, β-LPH and β-endorphin immunoreactivity rose in parallel, but plasma met-enkephalin did not change significantly. Sephadex G75 chromatography of samples taken at the time of the peak response (45 min) confirmed the rise in both β-LPH and β-endorphin. During administration of dexamethasone, 0.5 mg 6 hourly for 48 h, plasma cortisol and ACTH became undetectable at 24 h, and β-LPH and β-endorphin fell 0,15159 significantly by 24 h and were undetectable by 48 h; plasma met-enkephalin, however, showed no significant change. Nine adrenalectomized patients with Cushing's disease and four patients with Addison's disease had elevated plasma ACTH, β-LPH and β-endorphin but normal plasma met-enkephalin levels. Each of ten patients with renal failure had markedly elevated plasma met-enkephalin immunoreactivity which co-eluted with synthetic met-enkephalin on BioGel P4 chromatography. Trypsin and carboxypeptidase-B 0,15663 digestion of the P4 chromatography fractions generated met-enkephalin immunoreactivity in earlier fractions, indicating the presence of a potential high molecular weight met-enkephalin precursor. The results imply that different control mechanisms govern β-endorphin and met-enkephalin plasma levels and that the adrenal is not the only source of plasma met-enkephalin. The elevated levels of met-enkephalin in renal failure may be due to impaired clearance of met-enkephalin or of its precursor or to 0,16168 increased met-enkephalin production.

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APA Style

Smith, R., Grossman, A., Gaillard, R., Clement-Jones, V., Ratter, S., Mallinson, J., Lowry, P., Besser, G., & Rees, L. (1981). Studies on circulating met-enkephalin and beta-endorphin: normal subjects and patients with renal and adrenal disease. Clinical Endocrinology, 15(3), 291–300.

MLA Style

Smith, R, et al. “Studies on Circulating Met-Enkephalin and Beta-Endorphin: Normal Subjects and Patients with Renal and Adrenal Disease.” Clinical Endocrinology, vol. 15, no. 3, 1981, pp. 291–300.

Chicago Style

Smith, R, A Grossman, R Gaillard, et al. 1981. “Studies on Circulating Met-Enkephalin and Beta-Endorphin: Normal Subjects and Patients with Renal and Adrenal Disease.” Clinical Endocrinology 15 (3): 291–300.
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