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New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients

Abstract:

Despite many shortcomings, liver biopsy is regarded as the gold standard for assessing liver fibrosis. A less invasive and equally or more reliable approach would constitute a major advancement in the field. Proteomics can aid discovery of novel serological markers and these proteins can be measured in patient blood. A major challenge of discovering biomarkers in serum is the presence of highly abundant serum proteins, which restricts the levels of total protein loaded onto gels and limits th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/pr101077c

Authors


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Institution:
University of Oxford
Research group:
Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute
Department:
Medical Sciences Division - Biochemistry
More by this author
Institution:
University of Oxford
Research group:
Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute
Department:
Medical Sciences Division - Biochemistry
More by this author
Institution:
University of Oxford
Research group:
Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute
Department:
Medical Sciences Division - Biochemistry
More by this author
Institution:
University of Oxford
Research group:
Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute
Department:
Medical Sciences Division - Biochemistry
More by this author
Institution:
University of Oxford
Research group:
Oxford Antiviral Drug Discovery Unit, Oxford Glycobiology Institute
Department:
Medical Sciences Division - Biochemistry
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Funding agency for:
Bevin Gangadharan
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Funding agency for:
Robin Antrobus
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Funding agency for:
David Chittenden
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Proteome Research Journal website
Volume:
10
Issue:
5
Pages:
2643-2650
Publication date:
2011
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:039a9a3e-64cc-4533-9a51-ce3a50d731d3
Local pid:
ora:5973

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