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A genome-wide search for human type 1 diabetes susceptibility genes.

Abstract:

We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes mellitus using semi-automated fluorescence-based technology and linkage analysis. In addition to IDDM1 (in the major histocompatibility complex on chromosome 6p21) and IDDM2 (in the insulin gene region on chromosome 11p15), eighteen different chromosome regions showed some positive evidence of linkage to disease. Linkages to chromosomes 11q (IDDM4) and 6q (IDDM5) were confirmed by replication, a...

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Publisher copy:
10.1038/371130a0

Authors


Davies, JL More by this author
Kawaguchi, Y More by this author
Bennett, ST More by this author
Copeman, JB More by this author
Cordell, HJ More by this author
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Journal:
Nature
Volume:
371
Issue:
6493
Pages:
130-136
Publication date:
1994-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:0399ca00-943e-4562-ae3e-3b5569b84a2f
Source identifiers:
112357
Local pid:
pubs:112357

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