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Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501.

Abstract:

OBJECTIVE: The large multifunctional proteasome (LMP) molecules are over expressed in thyrocytes, the target cells of Graves' disease, and the LMP genes are found within the MHC class II region. The LMP genes may therefore play a role in susceptibility to Graves' disease. The aim of this this study was to determine whether polymorphisms of the LMP genes, LMP 2 and LMP 7 are in linkage disequilibrium with Graves' disease. DESIGN: Target DNA was amplified using the polymerase chain reaction. T...

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Journal:
Clinical endocrinology
Volume:
51
Issue:
1
Pages:
115-118
Publication date:
1999-07-01
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Source identifiers:
176218
Language:
English
Keywords:
Pubs id:
pubs:176218
UUID:
uuid:0389699b-2697-41b4-83f5-f60466a63470
Local pid:
pubs:176218
Deposit date:
2012-12-19

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