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Journal article

L-fucose from vitamin C with only acetonide protection.

Abstract:
Addition of human milk oligosaccharides (HMO) to baby foods may protect infants from disease. As many simple HMOs are fucosylated this is likely to increase the demand for L-fucose as a synthetic building block. Any chemical synthesis must be cheap to compete with a biotechnological process. Acetonide is the only protecting group we have used in this new synthesis of L-fucose from vitamin C in 27% overall yield (purification by recrystallization; no chromatography required in the entire sequence).
Publication status:
Published

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Publisher copy:
10.1021/ol502733x

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Publisher:
American Chemical Society
Journal:
Organic letters
Volume:
16
Issue:
21
Pages:
5663-5665
Publication date:
2014-11-01
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Source identifiers:
487025
Language:
English
Pubs id:
pubs:487025
UUID:
uuid:03814e52-04b7-4f1b-b070-5566d0126e56
Local pid:
pubs:487025
Deposit date:
2014-12-26

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