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Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1.

Abstract:

We studied the longitudinal relation between disease severity and titers of antigen-specific IgG subclasses in sera of patients with myasthenia gravis and antibodies to Muscle Specific Kinase (MuSK MG). Six patients were included of whom 55 samples had been collected during 2.5-13.4 years. Anti-MuSK antibodies were determined by ELISA and with a cell-based immunofluorescence assay. Disease severity was scored on a semi continuous scale. Only antigen-specific IgG4, and not IgG1, titers were si...

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Publication status:
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Authors


van Leeuwen, Y More by this author
Dekker, FW More by this author
Wintzen, AR More by this author
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Journal:
Journal of neuroimmunology
Volume:
195
Issue:
1-2
Pages:
151-156
Publication date:
2008-03-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:0381321d-dc4b-4f0d-9f38-2654dca29122
Source identifiers:
346352
Local pid:
pubs:346352

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