- Abstract:
-
Cellular damage from ionizing radiation (IR) is in part due to DNA damage and reactive oxygen species, which activate DNA damage response (DDR) and cytokine signaling pathways, including the ataxia telangiectasia mutated (ATM) and transforming growth factor (TGF)β/Smad pathways. Using classic double-strand breaks (DSBs) markers, we studied the roles of Smad proteins in DDR and the crosstalk between TGFβ and ATM pathways. We observed co-localization of phospho-Smad2 (pSmad2) and Smad7 with DSB...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/nar/gks1038
-
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- Journal:
- Nucleic acids research
- Volume:
- 41
- Issue:
- 2
- Pages:
- 933-942
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:03771d24-70be-4fc8-8af2-e16e27b5f745
- Source identifiers:
-
367720
- Local pid:
- pubs:367720
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways.
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