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Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways.

Abstract:

Cellular damage from ionizing radiation (IR) is in part due to DNA damage and reactive oxygen species, which activate DNA damage response (DDR) and cytokine signaling pathways, including the ataxia telangiectasia mutated (ATM) and transforming growth factor (TGF)β/Smad pathways. Using classic double-strand breaks (DSBs) markers, we studied the roles of Smad proteins in DDR and the crosstalk between TGFβ and ATM pathways. We observed co-localization of phospho-Smad2 (pSmad2) and Smad7 with DSB...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gks1038

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Journal:
Nucleic acids research
Volume:
41
Issue:
2
Pages:
933-942
Publication date:
2013-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:03771d24-70be-4fc8-8af2-e16e27b5f745
Source identifiers:
367720
Local pid:
pubs:367720

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