Journal article
Polyglutamine disease: from pathogenesis to therapy.
- Abstract:
-
Polyglutamine diseases are inherited neurodegenerative conditions arising from expanded trinucleotide CAG repeats in the disease-causing gene, which are translated into polyglutamine tracts in the resultant protein. Although these diseases share a common type of mutation, emerging evidence suggests that pathogenesis is complex, involving disruption of key cellular pathways, and varying with the disease context. An understanding of polyglutamine disease mechanisms is critical for development ...
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Bibliographic Details
- Journal:
- South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
- Volume:
- 102
- Issue:
- 6
- Pages:
- 481-484
- Publication date:
- 2012-06-01
- EISSN:
-
2078-5135
- ISSN:
-
0256-9574
- Source identifiers:
-
334764
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:334764
- UUID:
-
uuid:036f9a60-3a9f-4c5c-8913-976ba63b9143
- Local pid:
- pubs:334764
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2012
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