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Journal article

Polyglutamine disease: from pathogenesis to therapy.

Abstract:

Polyglutamine diseases are inherited neurodegenerative conditions arising from expanded trinucleotide CAG repeats in the disease-causing gene, which are translated into polyglutamine tracts in the resultant protein. Although these diseases share a common type of mutation, emerging evidence suggests that pathogenesis is complex, involving disruption of key cellular pathways, and varying with the disease context. An understanding of polyglutamine disease mechanisms is critical for development ...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Volume:
102
Issue:
6
Pages:
481-484
Publication date:
2012-06-01
EISSN:
2078-5135
ISSN:
0256-9574
Source identifiers:
334764
Language:
English
Keywords:
Pubs id:
pubs:334764
UUID:
uuid:036f9a60-3a9f-4c5c-8913-976ba63b9143
Local pid:
pubs:334764
Deposit date:
2013-11-17

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