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Journal article

Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis.

Abstract:

Catalytic antibodies that control the reaction pathways of the Diels-Alder cycloaddition have been generated. One antibody catalyzes the favored endo and the other the disfavored exo pathway to yield the respective cis and trans adducts in enantiomerically pure form. A comparison of the x-ray structure of the hapten with the calculated geometry of the transition structure showed that [2.2.2] bicyclic compounds are excellent mimics of the transition state of the Diels-Alder reaction. To achiev...

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Publication status:
Published

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Publisher copy:
10.1126/science.8211138

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
de Pascual-Teresa, B More by this author
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Journal:
Science (New York, N.Y.)
Volume:
262
Issue:
5131
Pages:
204-208
Publication date:
1993-10-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:036c9ab1-dd9d-4a44-9240-d3b92a8886e0
Source identifiers:
52137
Local pid:
pubs:52137

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