Journal article
Evolution and expansion of multidrug resistant malaria in Southeast Asia: a genomic epidemiology study
- Abstract:
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Background
A multidrug-resistant co-lineage of Plasmodium falciparum malaria, named KEL1/PLA1, spread across Cambodia in 2008–13, causing high rates of treatment failure with the frontline combination therapy dihydroartemisininpiperaquine. Here, we report on the evolution and spread of KEL1/PLA1 in subsequent years.Methods
For this genomic epidemiology study, we analysed whole genome sequencing data from P falciparum clinical samples collected from patients with malaria between ... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 452.0KB)
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- Publisher copy:
- 10.1016/S1473-3099(19)30392-5
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Lancet Infectious Diseases Journal website
- Volume:
- 19
- Issue:
- 9
- Pages:
- 943-951
- Publication date:
- 2019-07-22
- Acceptance date:
- 2019-06-20
- DOI:
- EISSN:
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1474-4457
- ISSN:
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1473-3099
- Source identifiers:
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1019635
Item Description
- Pubs id:
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pubs:1019635
- UUID:
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uuid:0367c10e-8f1b-45aa-b438-eff2e24612a2
- Local pid:
- pubs:1019635
- Deposit date:
- 2019-06-20
Terms of use
- Copyright holder:
- Hamilton et al
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
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