Internet publication
Global disparities in SARS-CoV-2 genomic surveillance
- Abstract:
- Genomic sequencing provides critical information to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments and vaccines, and guide public health responses. To investigate the spatiotemporal heterogeneity in the global SARS-CoV-2 genomic surveillance, we estimated the impact of sequencing intensity and turnaround times (TAT) on variant detection in 167 countries. Most countries submit genomes >21 days after sample collection, and 77% of low and middle income countries sequenced <0.5% of their cases. We found that sequencing at least 0.5% of the cases, with a TAT <21 days, could be a benchmark for SARS-CoV-2 genomic surveillance efforts. Socioeconomic inequalities substantially impact our ability to quickly detect SARS-CoV-2 variants, and undermine the global pandemic preparedness.
- Publication status:
- Published
- Peer review status:
- Not peer reviewed
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- Files:
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(Preview, Pre-print, pdf, 5.5MB, Terms of use)
-
- Publisher copy:
- 10.1101/2021.08.21.21262393
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 204311/Z/16/Z
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/S019510/1
+ National Heart Lung and Blood Institute
More from this funder
- Funder identifier:
- https://ror.org/012pb6c26
- Grant:
- T35 HL007649
- Host title:
- medRxiv
- Place of publication:
- United States
- Publication date:
- 2021-08-26
- DOI:
- Language:
-
English
- Keywords:
- Pubs id:
-
1193855
- Local pid:
-
pubs:1193855
- Deposit date:
-
2024-09-10
- ARK identifier:
Terms of use
- Copyright holder:
- Brito et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
- Notes:
- This is the pre-print version of the article. The final version is available online from Springer Nature at https://doi.org/10.1038/s41467-022-33713-y
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