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TP10, a delivery vector for decoy oligonucleotides targeting the Myc protein.

Abstract:

One approach to investigate gene function, by silencing the activity of certain proteins, is the usage of double stranded decoy oligodeoxynucleotides (ds decoy ODNs). Decoy, in this sense, is ds ODNs bearing the consensus binding sequence for a DNA-binding protein. This can be used in clinical settings to attenuate the effect of overexpressed transcription factors in tumor cells. We here choose to target the oncogenic protein Myc. Since oligonucleotides are poorly internalized to cells, a cel...

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Authors


El-Andaloussi, S More by this author
Johansson, H More by this author
Magnusdottir, A More by this author
Järver, P More by this author
Lundberg, P More by this author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
110
Issue:
1
Pages:
189-201
Publication date:
2005-12-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:0359a49b-a037-4ca6-9d61-1e4ec168bfeb
Source identifiers:
256405
Local pid:
pubs:256405

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