- Abstract:
-
One approach to investigate gene function, by silencing the activity of certain proteins, is the usage of double stranded decoy oligodeoxynucleotides (ds decoy ODNs). Decoy, in this sense, is ds ODNs bearing the consensus binding sequence for a DNA-binding protein. This can be used in clinical settings to attenuate the effect of overexpressed transcription factors in tumor cells. We here choose to target the oncogenic protein Myc. Since oligonucleotides are poorly internalized to cells, a cel...
Expand abstract - Publisher copy:
- 10.1016/j.jconrel.2005.09.012
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- Journal:
- Journal of controlled release : official journal of the Controlled Release Society
- Volume:
- 110
- Issue:
- 1
- Pages:
- 189-201
- Publication date:
- 2005-12-05
- DOI:
- EISSN:
-
1873-4995
- ISSN:
-
0168-3659
- URN:
-
uuid:0359a49b-a037-4ca6-9d61-1e4ec168bfeb
- Source identifiers:
-
256405
- Local pid:
- pubs:256405
- Copyright date:
- 2005
Journal article
TP10, a delivery vector for decoy oligonucleotides targeting the Myc protein.
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