Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes.

Journal article

Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed.

Authors: Fox, C; Darby, S; Ireland, J; Sönksen, P

• Publication status: Published
• Journal: British medical journal
• Volume: 2
• Issue: 6087
• Pages: 605-607
• Publication date: 1977-09-01
• DOI: 10.1136/bmj.2.6087.605
• EISSN: 1468-5833
• ISSN: 0007-1447
• Language: English
• Keywords: Basement Membrane; Diabetic Angiopathies; Animals; Body Weight; Male; Capillaries; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Kidney Glomerulus; Rats; Insulin; Blood Glucose