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Journal article

LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas.

Abstract:

Autophagy is a self-degradation mechanism by which cells recycle their own cytoplasmic constituents and dispose of excess or defective organelles after starvation and oxygen deprivation. An antibody to the microtubule-associated protein 1 light chain 3 (LC3A), recognizing both the soluble (LC3A-I) and the membrane-bound form (LC3A-II) of the protein, was used to detect autophagic activity in 102 breast carcinomas. Three distinct patterns were recognized: (1) diffuse cytoplasmic, (2) cytoplasm...

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Publication status:
Published

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Publisher copy:
10.2353/ajpath.2010.090049

Authors


Sivridis, E More by this author
Koukourakis, MI More by this author
Ferguson, DJ More by this author
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Journal:
The American journal of pathology
Volume:
176
Issue:
5
Pages:
2477-2489
Publication date:
2010-05-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:0353fe5b-6859-4275-84c9-459c4f8be485
Source identifiers:
119489
Local pid:
pubs:119489

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