- Abstract:
-
Autophagy is a self-degradation mechanism by which cells recycle their own cytoplasmic constituents and dispose of excess or defective organelles after starvation and oxygen deprivation. An antibody to the microtubule-associated protein 1 light chain 3 (LC3A), recognizing both the soluble (LC3A-I) and the membrane-bound form (LC3A-II) of the protein, was used to detect autophagic activity in 102 breast carcinomas. Three distinct patterns were recognized: (1) diffuse cytoplasmic, (2) cytoplasm...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2353/ajpath.2010.090049
-
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- Journal:
- The American journal of pathology
- Volume:
- 176
- Issue:
- 5
- Pages:
- 2477-2489
- Publication date:
- 2010-05-05
- DOI:
- EISSN:
-
1525-2191
- ISSN:
-
0002-9440
- URN:
-
uuid:0353fe5b-6859-4275-84c9-459c4f8be485
- Source identifiers:
-
119489
- Local pid:
- pubs:119489
- Copyright date:
- 2010
Journal article
LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas.
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