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Journal article

Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders.

Abstract:

As outlined elsewhere in this volume, sex differences can affect brain function and its dysfunction in psychiatric disorders. It is known that genetic factors contribute to these sex dimorphisms, but the individual genes have rarely been identified. The catechol-O-methyltransferase (COMT) gene, which encodes an enzyme that metabolises catechol compounds, including dopamine, is a leading candidate in this regard. COMT's enzyme activity, and the neurochemistry and behaviour of COMT knockout mic...

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Publisher copy:
10.1007/7854_2010_97

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Current topics in behavioral neurosciences
Volume:
8
Issue:
8
Pages:
119-140
Publication date:
2011-01-01
DOI:
EISSN:
1866-3389
ISSN:
1866-3370
URN:
uuid:034e9df0-10a6-4988-9787-29cd4fe698b5
Source identifiers:
166466
Local pid:
pubs:166466

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