Mapping cis- and trans-regulatory effects across multiple tissues in twins.

Journal article

Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals. Here, we present a comprehensive analysis of gene expression across multiple tissues conducted in a large set of mono- and dizygotic twins that allows systematic dissection of genetic (cis and trans) and non-genetic effects on gene expression...

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Authors: Grundberg, E; Small, K; Hedman, Å; Nica, A; Buil, A

• Publication status: Published
• Journal: Nature genetics
• Volume: 44
• Issue: 10
• Pages: 1084-1089
• Publication date: 2012-10-01
• DOI: 10.1038/ng.2394
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Subcutaneous Fat; Adult; Organ Specificity; Quantitative Trait Loci; Chromosome Mapping; Aged; Genetic Linkage; Polymorphism, Single Nucleotide; Lymphocytes; Aged, 80 and over; Skin; Female; Middle Aged; Transcription, Genetic; Gene Expression Regulation; Humans; Multiple Tissue Human Expression Resource (MuTHER) Consortium; Gene-Environment Interaction; Models, Genetic