Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.

Journal article

The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

Authors: Chamberlain, J; Grant, S; Reeves, A; Mullins, L; Stephenson, D

• Publication status: Published
• Publisher: Kluwer Academic Publishers-Plenum Publishers
• Journal: Somatic cell and molecular genetics
• Volume: 13
• Issue: 6
• Pages: 671-678
• Publication date: 1987-11-01
• DOI: 10.1007/bf01534487
• EISSN: 1572-9931
• ISSN: 0740-7750
• Language: English
• Keywords: Polymorphism, Restriction Fragment Length; Genetic Linkage; Species Specificity; DNA; Chromosome Mapping; Mutation; Muscular Dystrophy, Animal; Mice; Humans; X Chromosome; Animals; Disease Models, Animal; Nucleic Acid Hybridization