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Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes.

Abstract:

ROS production is an important effector mechanism mediating intracellular killing of microbes by phagocytes. Inappropriate or untimely ROS production can lead to tissue damage, thus tight regulation is essential. We recently characterized signal inhibitory receptor on leukocytes-1 (SIRL-1) as an inhibitory receptor expressed by human phagocytes. Here, we demonstrate that ligation of SIRL-1 dampens Fc receptor-induced ROS production in primary human phagocytes. In accordance, SIRL-1 engagement...

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Publisher copy:
10.1002/eji.201242916

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
European journal of immunology
Volume:
43
Issue:
5
Pages:
1297-1308
Publication date:
2013-05-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:0344fdef-5f0c-42d7-b727-593d9e6e38c9
Source identifiers:
387317
Local pid:
pubs:387317

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