Journal article
Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry.
- Abstract:
- The copper-catalyzed azide-alkyne cycloaddition reaction has been used for the template-mediated chemical ligation of two oligonucleotide strands, one with a 5'-alkyne and the other with a 3'-azide, to produce a DNA strand with an unnatural backbone at the ligation point. A template-free click-ligation reaction has been used for the intramolecular circularization of a single stranded oligonucleotide which was used as a template for the synthesis of a covalently closed DNA catenane.
- Publication status:
- Published
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- Publisher copy:
- 10.1021/ja070273v
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Authors
Bibliographic Details
- Journal:
- Journal of the American Chemical Society
- Volume:
- 129
- Issue:
- 21
- Pages:
- 6859-6864
- Publication date:
- 2007-05-05
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- URN:
-
uuid:03426667-1e57-43da-8a04-ce7b3e574c63
- Source identifiers:
-
400028
- Local pid:
- pubs:400028
Item Description
Terms of use
- Copyright date:
- 2007
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