Thesis icon

Thesis

An investigation into persistent transgene expression from plasmid vectors in the lung

Abstract:

Gene therapy for chronic lung diseases will require vectors capable of persistent transgene expression in the absence of inflammation but few promoters have been identified that can fulfil both of these requirements. The development of plasmids devoid of CG dinucleotides (CpGs) has resulted in markedly reduced levels of pro-inflammatory cytokines. Furthermore, a novel synthetic enhancer/promoter, termed hCEFI, has been shown to direct high levels of sustained transgene expression in the mu...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Department:
University of Oxford

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
More from this funder
Grant:
G0900198-1/1
Funding agency for:
Project
More from this funder
Grant:
G1000402-1/1
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP