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Identification of a novel clinical phenotype of severe Malaria using a network-based clustering approach

Abstract:

The parasite Plasmodium falciparum is the main cause of severe malaria (SM). Despite treatment with antimalarial drugs, more than 400,000 deaths are reported every year, mainly in African children. The diversity of clinical presentations associated with SM highlights important differences in disease pathogenesis that often require specific therapeutic options. The clinical heterogeneity of SM is largely unresolved. Here we report a network-based analysis of clinical phenotypes associated with...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-018-31320-w

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Casals-Pascual, C
Bill & Melinda Gates Foundation More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 12849
Publication date:
2018-08-27
Acceptance date:
2018-08-14
DOI:
ISSN:
2045-2322
Pubs id:
pubs:907563
URN:
uri:0334cdc0-8891-474f-85ee-7e08ea594c1a
UUID:
uuid:0334cdc0-8891-474f-85ee-7e08ea594c1a
Local pid:
pubs:907563

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