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Pacing a small cage: mutation and RNA viruses.

Abstract:

RNA viruses have an extremely high mutation rate, and we argue that the most plausible explanation for this is a trade-off with replication speed. We suggest that research into further increasing this mutation rate artificially as an antiviral treatment requires a theoretical reevaluation, especially relating to the so-called error threshold. The main evolutionary consequence of a high mutation rate appears to have been to restrict RNA viruses to a small genome; they thus rapidly exploit a li...

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Publication status:
Published

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Publisher copy:
10.1016/j.tree.2007.11.010

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Trends in ecology and evolution
Volume:
23
Issue:
4
Pages:
188-193
Publication date:
2008-04-05
DOI:
EISSN:
1872-8383
ISSN:
0169-5347
URN:
uuid:0326afa3-ed2e-4537-95e2-d8161abdcff8
Source identifiers:
209267
Local pid:
pubs:209267

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