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T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production.

Abstract:

EBV is associated with a broad range of malignancies. Adoptive immunotherapy of these tumors with EBV-specific CTL proved useful. We generated a panel of primary human T cells specific to various EBV antigens (i.e. Epstein-Barr nuclear antigen 3A, 3B and BamHI-M leftward reading frame) via transfer of modified TCR genes that are either coupled to CD3zeta or Fc(epsilon)RIgamma. TCR-transduced T cells from 20-60% of donors (total number of 25) demonstrated specific lysis of EBV peptide-loaded t...

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Publication status:
Published

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Publisher copy:
10.1093/intimm/dxh401

Authors


Lankiewicz, B More by this author
Drexhage, J More by this author
Berrevoets, C More by this author
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Journal:
International immunology
Volume:
18
Issue:
4
Pages:
591-601
Publication date:
2006-04-05
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:03233ce2-05a6-41cf-bc68-acca04d1e4fc
Source identifiers:
39847
Local pid:
pubs:39847

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