Journal article
T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production.
- Abstract:
-
EBV is associated with a broad range of malignancies. Adoptive immunotherapy of these tumors with EBV-specific CTL proved useful. We generated a panel of primary human T cells specific to various EBV antigens (i.e. Epstein-Barr nuclear antigen 3A, 3B and BamHI-M leftward reading frame) via transfer of modified TCR genes that are either coupled to CD3zeta or Fc(epsilon)RIgamma. TCR-transduced T cells from 20-60% of donors (total number of 25) demonstrated specific lysis of EBV peptide-loaded t...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/intimm/dxh401
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Authors
Bibliographic Details
- Journal:
- International immunology
- Volume:
- 18
- Issue:
- 4
- Pages:
- 591-601
- Publication date:
- 2006-04-05
- DOI:
- EISSN:
-
1460-2377
- ISSN:
-
0953-8178
- URN:
-
uuid:03233ce2-05a6-41cf-bc68-acca04d1e4fc
- Source identifiers:
-
39847
- Local pid:
- pubs:39847
Item Description
Terms of use
- Copyright date:
- 2006
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