The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.

Journal article

Herpesviruses employ many mechanisms to evade the immune response, allowing them to persist life-long in their hosts. The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) and, more recently, the latency-associated nuclear antigen 1 (LANA-1) of the Kaposi Sarcoma Herpesvirus have been shown to function as in cis-acting inhibitors of antigen presentation. In both proteins, long simple repeat elements are responsible for the inhibition, but the sequences of these repeats are strongly dissimil...

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Authors: Ossevoort, M; Zaldumbide, A; te Velthuis, A; Melchers, M; Ressing, M

• Journal: Molecular immunology
• Volume: 44
• Issue: 14
• Pages: 3588-3596
• Publication date: 2007-07-01
• DOI: 10.1016/j.molimm.2007.03.005
• EISSN: 1872-9142
• ISSN: 0161-5890
• Language: English
• Keywords: Amino Acid Sequence; Molecular Sequence Data; Epstein-Barr Virus Nuclear Antigens; Open Reading Frames; Humans; Cell Line; Mice; Recombinant Fusion Proteins; Antigen Presentation; beta-Galactosidase; Base Sequence; RNA, Messenger; Peptides; T-Lymphocytes, Cytotoxic; Animals; Viral Proteins