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The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.

Abstract:

Herpesviruses employ many mechanisms to evade the immune response, allowing them to persist life-long in their hosts. The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) and, more recently, the latency-associated nuclear antigen 1 (LANA-1) of the Kaposi Sarcoma Herpesvirus have been shown to function as in cis-acting inhibitors of antigen presentation. In both proteins, long simple repeat elements are responsible for the inhibition, but the sequences of these repeats are strongly dissimil...

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Journal:
Molecular immunology More from this journal
Volume:
44
Issue:
14
Pages:
3588-3596
Publication date:
2007-07-01
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
Language:
English
Keywords:
Pubs id:
pubs:375264
UUID:
uuid:031dfe65-da29-4b71-b2ad-fb0b2a78e666
Local pid:
pubs:375264
Source identifiers:
375264
Deposit date:
2013-11-16

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