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Chromosomal integration of the Klebsiella pneumoniae carbapenemase gene (blaKPC) in Klebsiella species: Elusive but not rare

Abstract:

Carbapenemase genes in Enterobacteriaceae are mostly described as being plasmid-associated. However, the genetic context of carbapenemase genes is not always confirmed in epidemiological surveys, and the frequency of their chromosomal integration is therefore unknown.


A previously sequenced collection of blaKPC-positive Enterobacteriaceae from a single US institution (2007-2012; n=281 isolates, 182 patients) was analyzed to identify chromosomal insertions of Tn4401, the trans...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/AAC.01823-16

Authors


Mathers, AJ More by this author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Carroll, J More by this author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
61
Issue:
3
Pages:
e01823-16
Publication date:
2016-12-05
Acceptance date:
2016-12-12
DOI:
ISSN:
1098-6596
Pubs id:
pubs:665064
URN:
uri:031c722f-9f72-40c1-af7a-656f5fa91580
UUID:
uuid:031c722f-9f72-40c1-af7a-656f5fa91580
Local pid:
pubs:665064

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