GeneRecon--a coalescent based tool for fine-scale association mapping.

Journal article

UNLABELLED: GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable. AVAILABILITY: The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/~mailund/GeneRecon CONTACT: [email protected].

Authors: Mailund, T; Schierup, M; Pedersen, C; Madsen, J; Hein, J

• Publication status: Published
• Journal: Bioinformatics (Oxford, England)
• Volume: 22
• Issue: 18
• Pages: 2317-2318
• Publication date: 2006-09-01
• DOI: 10.1093/bioinformatics/btl153
• EISSN: 1367-4811
• ISSN: 1367-4803
• Language: English
• Keywords: Chromosome Mapping; Genetic Predisposition to Disease; Linkage Disequilibrium; Sequence Analysis, DNA; Genetics, Population; Models, Statistical; DNA Mutational Analysis; Genetic Linkage; Software; Algorithms; Humans; Models, Genetic; Animals