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Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP

Abstract:

The new and growing family of interleukin-1β-converting enzyme (ICE) cysteine proteases are now recognised to be major effectors of cellular death by apoptosis. Like other members of this family, the CPP32/Yama proform is activated by processing to its active heterodimeric enzyme or apopain when it likely contributes to the process of apoptosis by cleaving poly(ADP-ribose) polymerase (PARP) and thereby inhibiting much of its DNA repair activity. Apoptosis plays a fundamental role in the regul...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/0014-5793(96)00427-9

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Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
Leukaemia Research More from this funder
Royal Society More from this funder
Publisher:
Elsevier B.V. Publisher's website
Journal:
FEBS Letters Journal website
Volume:
386
Issue:
2-3
Pages:
115-122
Publication date:
1996-05-05
DOI:
EISSN:
9600-4279
ISSN:
0014-5793
URN:
uuid:03124e78-2aba-40b5-a72e-dbb4a54ea487
Local pid:
ora:8512
Language:
English
Keywords:
Subjects:

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