Journal article
Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP
- Abstract:
-
The new and growing family of interleukin-1β-converting enzyme (ICE) cysteine proteases are now recognised to be major effectors of cellular death by apoptosis. Like other members of this family, the CPP32/Yama proform is activated by processing to its active heterodimeric enzyme or apopain when it likely contributes to the process of apoptosis by cleaving poly(ADP-ribose) polymerase (PARP) and thereby inhibiting much of its DNA repair activity. Apoptosis plays a fundamental role in the regul...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.1MB, Terms of use)
-
- Publisher copy:
- 10.1016/0014-5793(96)00427-9
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- FEBS Letters More from this journal
- Volume:
- 386
- Issue:
- 2-3
- Pages:
- 115-122
- Publication date:
- 1996-05-01
- DOI:
- EISSN:
-
9600-4279
- ISSN:
-
0014-5793
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:03124e78-2aba-40b5-a72e-dbb4a54ea487
- Local pid:
-
ora:8512
- Deposit date:
-
2014-06-03
Terms of use
- Copyright holder:
- Federation of European Biochemical Societies
- Copyright date:
- 1996
- Notes:
- Copyright © 1996 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/
- Licence:
- Other
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record