The structure of foot-and-mouth disease virus.

Journal article

Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.

Authors: Fry, E; Stuart, D; Rowlands, D

• Publication status: Published
• Journal: Current topics in microbiology and immunology
• Volume: 288
• Pages: 71-101
• Publication date: 2005-01-01
• ISSN: 0070-217X
• Language: English
• Keywords: Capsid Proteins; Receptors, Virus; Viral Nonstructural Proteins; Virus Assembly; Integrins; Genome, Viral; Heparan Sulfate Proteoglycans; Foot-and-Mouth Disease Virus