The structural basis of nuclear function.

Journal article

Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.

Authors: Jackson, D; Cook, P

• Publication status: Published
• Journal: International review of cytology
• Volume: 162A
• Pages: 125-149
• Publication date: 1995-01-01
• ISSN: 0074-7696
• Language: English
• Keywords: Nuclear Matrix; Animals; Cell Nucleus; Protein Conformation; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; Chromatin; Humans