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Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara.

Abstract:

Many recombinant poxviral vaccines are currently in clinical trials for cancer and infectious diseases. However, these agents have failed to generate T cell responses specific for recombinant gene products at levels comparable with T cell responses associated with natural viral infections. The recent identification of vaccinia-encoded CTL epitopes, including a new epitope described in this study, allows the simultaneous comparison of CTL responses specific for poxviral and recombinant epitope...

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Publication status:
Published

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Authors


Pasquetto, V More by this author
Tscharke, DC More by this author
Palmowski, MJ More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
12
Pages:
8431-8437
Publication date:
2005-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:02fbe9f6-a7ea-4e2f-b65f-c85d1b3b7564
Source identifiers:
33326
Local pid:
pubs:33326

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