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Journal article

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.

Abstract:

Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue homeostasis. Mutant receptor kinase domains escape regulation leading to severely degenerative diseases and represent an important therapeutic target. Fibrodysplasia ossificans progressiva (FOP) is a rare but devastating disorder of extraskeletal bone formation. FOP-associated mutations in the BMP receptor ALK2 reduce binding of the inhibitor FKBP12 and promote leaky signaling in the abse...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m112.365932

Authors


Chaikuad, A More by this author
Sanvitale, CE More by this author
Boergermann, JH More by this author
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Journal:
The Journal of biological chemistry
Volume:
287
Issue:
44
Pages:
36990-36998
Publication date:
2012-10-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:02f905d4-872b-4075-8c57-59432b06fed5
Source identifiers:
350647
Local pid:
pubs:350647

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