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Journal article

Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2

Abstract:

Adenovirus vector vaccines have been widely and successfully deployed in response to coronavirus disease 2019 (COVID-19). However, despite inducing potent T cell immunity, improvement of vaccine-specific antibody responses upon homologous boosting is modest compared with other technologies. Here, we describe a system enabling modular decoration of adenovirus capsid surfaces with antigens and demonstrate potent induction of humoral immunity against these displayed antigens. Ligand attachmen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ymthe.2022.08.002

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Role:
Author
ORCID:
0000-0003-1909-7095
Publisher:
Cell Press
Journal:
Molecular Therapy More from this journal
Volume:
30
Issue:
12
Pages:
3639-3657
Publication date:
2022-08-09
Acceptance date:
2022-08-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Pmid:
35949171
Language:
English
Keywords:
Pubs id:
1274354
Local pid:
pubs:1274354
Deposit date:
2022-12-01

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