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Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes.

Abstract:

The mammalian epidermis is a continually renewing structure that provides the interface between the organism and an innately hostile environment. The keratinocyte is its principal cell. Keratinocyte proteins form a physical epithelial barrier, protect against microbial damage, and prepare immune responses to danger. Epithelial immunity is disordered in many common diseases and disordered epithelial differentiation underlies many cancers. In order to identify the genes that mediate epithelial ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0007651

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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Institution:
University of Oxford
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Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
10
Pages:
Article: e7651
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:02e42eaf-0c87-446b-bae9-73b3538cadf4
Source identifiers:
34958
Local pid:
pubs:34958

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