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Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the Parkinsonian rat

Abstract:

Much of the motor impairment associated with Parkinson's disease is thought to arise from pathological activity in the networks formed by the basal ganglia (BG) and motor cortex. To evaluate several hypotheses proposed to explain the emergence of pathological oscillations in Parkinsonism, we investigated changes to the directed connectivity in BG networks following dopamine depletion. We recorded local field potentials (LFPs) in the cortex and basal ganglia of rats rendered Parkinsonian by in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1152/jn.00629.2017

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
BNDU
Oxford college:
Exeter College
Role:
Author
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Funding agency for:
West, TO
Grant:
EP/F500351/1
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Funding agency for:
Halliday, DM
Grant:
EP/N007050/1
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Funding agency for:
Sharott, A
Grant:
MC_UU_21024/1
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Funding agency for:
Magill, PJ
Grant:
G-0806
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Funding agency for:
Magill, PJ
Grant:
G-0806
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Publisher:
American Physiological Society Publisher's website
Journal:
Journal of Neurophysiology Journal website
Volume:
119
Issue:
5
Pages:
1608-1628
Publication date:
2018-01-10
Acceptance date:
2018-01-03
DOI:
ISSN:
1522-1598 and 0022-3077
Pmid:
29357448
Source identifiers:
821498
Language:
English
Keywords:
Pubs id:
pubs:821498
UUID:
uuid:02dc2137-46f8-4f13-8ea0-5ffe393b73ab
Local pid:
pubs:821498
Deposit date:
2018-02-19

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