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Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels.

Abstract:

Oxaliplatin, an effective cytotoxic treatment in combination with 5-fluorouracil for colorectal cancer, is associated with sensory, motor and autonomic neurotoxicity. Motor symptoms include hyperexcitability while autonomic effects include urinary retention, but the cause of these side-effects is unknown. We examined the effects on motor nerve function in the mouse hemidiaphragm and on the autonomic system in the vas deferens. In the mouse diaphragm, oxaliplatin (0.5 mM) induced multiple endp...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0706407

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
British journal of pharmacology
Volume:
146
Issue:
7
Pages:
1027-1039
Publication date:
2005-12-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:02db7680-ef65-4410-a0e8-c9e4167756bc
Source identifiers:
241883
Local pid:
pubs:241883

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