- Abstract:
-
Oxaliplatin, an effective cytotoxic treatment in combination with 5-fluorouracil for colorectal cancer, is associated with sensory, motor and autonomic neurotoxicity. Motor symptoms include hyperexcitability while autonomic effects include urinary retention, but the cause of these side-effects is unknown. We examined the effects on motor nerve function in the mouse hemidiaphragm and on the autonomic system in the vas deferens. In the mouse diaphragm, oxaliplatin (0.5 mM) induced multiple endp...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.bjp.0706407
-
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- Journal:
- British journal of pharmacology
- Volume:
- 146
- Issue:
- 7
- Pages:
- 1027-1039
- Publication date:
- 2005-12-05
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- URN:
-
uuid:02db7680-ef65-4410-a0e8-c9e4167756bc
- Source identifiers:
-
241883
- Local pid:
- pubs:241883
- Copyright date:
- 2005
Journal article
Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels.
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