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Journal article

Relative resistance of HIV-1 founder viruses to control by interferon-alpha.

Abstract:

BACKGROUND: Following mucosal human immunodeficiency virus type 1 (HIV-1) transmission, type 1 interferons (IFNs) are rapidly induced at sites of initial virus replication in the mucosa and draining lymph nodes. However, the role played by IFN-stimulated antiviral activity in restricting HIV-1 replication during the initial stages of infection is not clear. We hypothesized that if type 1 IFNs exert selective pressure on HIV-1 replication in the earliest stages of infection, the founder viruse...

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Publication status:
Published

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Publisher copy:
10.1186/1742-4690-10-146

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Journal:
Retrovirology
Volume:
10
Issue:
1
Pages:
146
Publication date:
2013-01-01
DOI:
EISSN:
1742-4690
ISSN:
1742-4690
URN:
uuid:02dafff6-9355-473d-b3cc-5fd950e1e3de
Source identifiers:
441707
Local pid:
pubs:441707

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